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CyFlow™ CD3 zeta Purified

1.043,00 DKK*

Prices net excl. VAT, plus applicable shipping costs

Antigen:	CD3 ζ (Phospho-Tyr72)
Clone:	EM-26
Application:	Flow cytometry, Immunocytochemistry, Western blot
Format/Fluorochrome:	Purified
Target Species:	Human, Mouse
Field of Interest:	Immunophenotyping
Species of Origin:	Mouse
Regulatory Status:	RUO
Clonality:	monoclonal
Isotype:	IgG1

HLDA Workshop	HLDA VI—WS Code T 6T-CD3.1
Concentration Unit	mg/mL
Concentration	1
Quantity	0.1 mg
Volume	0.1
Immunogen	A phospho specific peptide corresponding to the amino acids surrounding tyrosine 72 of mouse CD3 ζ linked to KLH
Background Information	CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3γ, CD3 δ, CD3ε and CD3ζ. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
Storage Buffer	The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
Storage	Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Stability	Do not use after expiration date stamped on vial label.

Specific References

| Dopfer EP, Schöpf B, Louis-Dit-Sully C, Dengler E, Höhne K, Klescová A, Prouza M, Suchanek M, Reth M, Schamel WW: Analysis of novel phospho‑ITAM specific antibodies in a S2 reconstitution system for TCR‑CD3 signalling. Immunol·Lett. 2010·May·4; 130(1‑2):43‑50. <·PMID:·20005895·> | Borroto A, Arellano I, Dopfer EP, Prouza M, Suchanek M, Fuentes M, Orfao A, Schamel WW, Alarcón B: Nck recruitment to the TCR required for ZAP70 activation during thymic development. J·Immunol. 2013·Feb·1; 190(3):1103‑12. <·PMID:·23267019·>

Available Technical Data Sheets

CyFlow™ CD3 zeta Purified (EM-26) CK521072 TDS (US)